Researchers at Russia’s Tomsk Polytechnic University (TPU) have successfully synthesized novel organic compounds exhibiting significant antitumor properties. These compounds hold potential for the development of new therapeutic agents targeting prostate adenocarcinoma, ovarian cancer, and breast cancer.
A notable feature of these newly developed compounds is their remarkable efficacy; they require a lower concentration to inhibit cancer cell growth compared to existing medications. According to the university’s press service, this characteristic not only enhances the cost-effectiveness of the compounds but also suggests a reduced toxicity profile.
The research was based on quinones, which are organic compounds recognized for their biological activity. These substances are already utilized in medical applications as anti-tuberculosis, anti-malarial, anti-microbial, and anti-tumor agents, as well as fungicides. However, the TPU team advanced this field by synthesizing derivatives of 1,4-naphthoquinone fluorosulfate and investigating their electrochemical and biological properties.
“The synthesized compounds were evaluated against prostate, ovarian, and breast cancer cell lines. The results indicate a high level of antitumor activity, warranting further investigation for their application in chemotherapy,” stated Evgeny Plotnikov, associate professor at the Research School of Chemical and Biomedical Technologies and a co-author of the study, in an interview with Nauka.rf.
The findings reveal that certain synthesized compounds exhibit greater cytotoxicity, or the ability to damage cancer cells than currently used platinum-based drugs in clinical settings.
Additionally, the researchers focused on developing a method to quantify the synthesized compounds within medicinal formulations. “This method will ensure that the drugs adhere to quality standards and pharmacological criteria,” remarked Elena Korotkova, head of the chemical engineering department at the TPU School of Natural Resources Engineering.
The study involved collaboration among various departments within TPU, including the School of Natural Resources Engineering, Advanced Manufacturing Technologies, and the Research School of Chemical and Biomedical Engineering.
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